相关实验视频
Updated: May 4, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
16.5K
概括
具有基因突变的初级粘膜黑色素瘤患者经历了更长时间的疾病控制. S100蛋白水平可以预测瘤进展,并有助于对这种罕见癌症的风险分层.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 黑色素瘤研究研究
背景情况:
- 初级粘膜黑色素瘤是一种罕见的恶性瘤,原因不明,预后不佳.
- 诊断往往发生在较晚的阶段,限制治疗的有效性.
研究的目的:
- 研究中国西南地区原发性粘膜黑色素瘤的临床和实验室特征.
- 确定疾病进展的潜在预后标志物.
主要方法:
- 对28名原发性粘膜黑色素瘤患者的临床和实验室数据的分析.
- 基因突变的评估,淋巴细胞与单细胞的比率,乙素细胞数量和S100蛋白质水平.
- 实验室发现与瘤起源,转移和复发的相关性.
主要成果:
- 在25%的患者中发现了基因突变,与复发风险降低有关.
- 黑色素瘤的起源各不相同:头部/部 (46%),阳肠 (43%),生殖道 (11%).
- 在诊断时S100蛋白水平升高预测器官转移 (AUC=0.924).
结论:
- 基因突变与原发性粘膜黑色素瘤中改善的疾病控制生存率相关.
- S100蛋白是预测瘤进展和改善患者风险分层的宝贵生物标志物.
更多相关视频
相关概念视频
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81