细菌 Fragilis 毒素的机械多样性和单域抗体的中和

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A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Yucheng Guo1, Zhenlin Ouyang2, Wenbo He2

  • 1Center for Microbiome Research of Med-X Institute, Department of Critical Care Medicine, Shaanxi Provincial Key Laboratory of Sepsis in Critical Care Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China; The Key Laboratory of Environment and Genes Related to Disease of Ministry of Education, Health Science Center, Basic Medical Science, Xi'an Jiaotong University, Xi'an 710061, China; School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Cell chemical biology
|January 16, 2026
PubMed
概括

肠毒性细菌菌体易碎 (ETBF) 导致结肠炎症. 研究人员开发了一种纳米体,Nb2.43,可以中和BFT毒素,并防止ETBF诱导的小鼠损伤.

关键词:
这种毒素是 Bacteroides fragilis 的毒素.这是E-cadherin.肠毒性 细菌类 细菌类 易碎的主体-病原体相互作用这是一种金属酶 (metaloenzyme).中和化 中和化 中和化一个单域抗体.结构和功能结构和功能.

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