端粒长度和与代谢功能障碍相关的脂肪性肝病风险和进展:系统性审查和元分析
Chunfeng Sun1, Ping Qiu2, Shuo Huang3
1Department of Infectious Disease, the First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, China.
Experimental gerontology
|January 16, 2026
概括
短端粒长度 (TL) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险增加和进展有关. 纵向研究为这种关联提供了比横截面数据更有力的证据.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 遗传学是一种遗传学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 端粒长度 (TL) 是细胞衰老和压力的生物标志物.
- 需要系统地评估TL和MASLD风险/进展之间的关系.
研究的目的:
- 系统地审查和综合有关端粒长度 (TL) 和MASLD风险之间的相关证据.
- 评估TL在MASLD进展结果中的作用.
主要方法:
- 在PubMed,EMBASE和Web of Science的系统文献搜索.
- 包括符合PRISMA 2020指南的12项观察性研究.
- 使用随机效应模型进行定量分析.
主要成果:
- 较短的白细胞端粒长度 (LTL) 与MASLD风险增加有关,特别是在纵向队列研究中.
- 横截面研究显示了不一致的发现,在MASLD的T2DM患者中,LTL的潜在悖论性增加.
- 加快的LTL消耗,而不是基线长度,是MASLD发病率的关键预测因素.
- 较短的LTL可能表明严重的MASLD进展,尽管存在方法上的限制.
结论:
- 较短的TL是MASLD风险的潜在生物标志物,由纵向数据支持.
- 定量分析揭示了显著的关联,但异质性和偏见需要谨慎.
- 较短的TL可能与不良的MASLD进展相关.
- 需要高质量的纵向研究来确认临床效用.
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