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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Regulation of Expression at Multiple Steps01:23

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Inheritance01:25

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Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
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Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
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Updated: Jan 18, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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DMDGRN:基于数据增强的多层定向图形卷积网络,用于基因调节网络推断.

Pi-Jing Wei1, Mingzhu Sun1, Zheng Ding1

  • 1The Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education, Institute of Physical Science and Information Technology, Anhui University, 111 Jiulong Road, Hefei 230601, Anhui, China.

Journal of biomedical informatics
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PubMed
概括
此摘要是机器生成的。

DMDGRN是一种新的图形神经网络方法,通过解决方向性和稀疏性来增强基因调节网络 (GRN) 的推断. 这种方法成功地确定了乳腺癌的治疗点,推进了计算生物学和翻译医学.

关键词:
数据增强数据增强定向图形卷积网络 定向图形卷积网络基因监管网络 基因监管网络稀疏的图形是稀疏的

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科学领域:

  • 系统生物学 系统生物学
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 基因调控网络 (GRNs) 模型转录因子和基因之间的相互作用,对于细胞身份和疾病发病过程至关重要.
  • 图形神经网络 (GNN) 对GRN推断有前途,但往往忽视GRN特征,如方向性和稀疏性.
  • 准确的GRN推断是理解复杂的生物系统和疾病机制的关键挑战.

研究的目的:

  • 为改进GRN推断开发一种基于GNN的新方法.
  • 通过结合方向性和稀疏性考虑来解决现有方法的局限性.
  • 应用开发的方法来确定乳腺癌的治疗点.

主要方法:

  • 提出DMDGRN,一个基于数据增强的多层定向图形卷积网络,用于GRN推理.
  • 使用拉普拉斯运算符的相矩阵来捕获GRN方向性并跟踪消息传播.
  • 采用数据增强和多层定向网络与剩余连接来处理稀疏性和提取更高阶信息.

主要成果:

  • DMDGRN显著提高了对基准数据集的GRN推断准确性.
  • 该方法成功地确定了人类乳腺癌的相关治疗候选者.
  • 评估证实了数据增强和GRN推理的多层定向架构的有效性.

结论:

  • 在DMDGRN中采用的策略对于推断基因调节网络是有效的.
  • DMDGRN显示出发现与疾病相关的调节机制和确定治疗点的潜力.
  • 这种方法是推进计算生物学和翻译医学的一个有前途的工具.