具有骨质生成和抗炎性质的均结构生物材料的无容器制造
Xinchun Liu1, Zhibo Yang2, Yanling Zhou2
1State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences 1295 Dingxi Road, Shanghai 200050, P. R. China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences 19A Yuquan Road, Beijing 100049, P. R. China.
Acta biomaterialia
|January 16, 2026
概括
使用无容器加工开发的新型生物活性玻璃 (LCS-CP) 保持温和的性pH值,促进骨再生和减少炎症. 这种生物材料将生物活性与生物安全相协调,以改善组织修复.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 材料化学 材料化学
背景情况:
- 生物材料经常面临生物活性和维持生理稳态之间的冲突.
- 像生物陶和生物玻璃这样的无机生物材料可能会由于离子释放而导致过度化,从而限制了它们的临床应用.
- 开发支持组织愈合的生物活性材料,同时尊重身体的自然平衡,是一个关键的挑战.
研究的目的:
- 使用无容器加工开发一种均的--酸盐生物活性玻璃 (LCS-CP).
- 为了研究LCS-CP的溶解行为,离子释放概况和pH调节.
- 评估体外和体内生物反应,包括干细胞分化,炎症调节和组织修复.
主要方法:
- 采用无容器加工,合成了一种均的--酸盐生物活性玻璃 (LCS-CP).
- 随着时间的推移,在Tris-HCl和细胞培养基中监测了溶解行为和离子释放 (Li,Si,Ca).
- 细胞增殖,骨髓介质干细胞 (BMSCs) 的骨质基因分化,以及炎症反应 (中性粒细胞激活,细胞因子分泌) 在体外评估.
- 在体内研究评估了早期的炎症反应和植入后的组织修复.
主要成果:
- 在50天内,LCS-CP保持了温和的性微环境 (细胞培养中的pH<8.0;Tris-HCl中的<9.2).
- 与其晶体对应物相比,LCS-CP表现出调节的散装溶解和较低的Li/Si释放.
- LCS-CP促进了BMSC的扩散和骨质分化,缓解了中性粒细胞过度活化,并减少了促炎因子分泌.
- 在体内,LCS-CP减少了早期炎症,并支持组织修复.
结论:
- 无容器加工产生一种同质的生物活性玻璃 (LCS-CP),具有更好的恒温兼容性.
- LCS-CP有效地将生物活性与生物安全性相协调,证明了增强组织再生的潜力.
- 这种方法为设计适应性生物材料用于再生医学提供了新的策略.
相关概念视频
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01:40Bone Remodeling
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01:23Bone as Supporting Connective Tissue
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Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:30Bone Cells and Tissue
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Osteoblasts and Osteocytes
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Osteoblasts and Osteocytes
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01:18The Bone Matrix
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The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...