相关实验视频

Updated: Aug 15, 2026

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
11:25

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Published on: March 18, 2017

10.0K

通过机械化学合来调节G-四重复合/血红蛋白DNA酶过氧化酶模仿活性

Hui Zhang1, Shengjie Gao1, Zhiwen Guan1

  • 1School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.

Analytica chimica acta
|January 16, 2026
PubMed
概括

这项研究介绍了一种机械化学策略,使用DNA子来提高G-四重复 (G4) /血红蛋白DNA酶活性和稳定性. 这种方法提高了催化效率和对环境干扰的强度,推进了生物传感应用.

关键词:
这就是DNAzyme DNA酶.在G-quadruplex中使用.机械化学合器 机械化学合器过氧酶模仿活动的活性.

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相关概念视频

Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
PCR01:32

PCR

Overview
Genome Copying Errors02:46

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
PCR - Polymerase Chain Reaction01:32

PCR - Polymerase Chain Reaction

Overview
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...