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Updated: Jan 18, 2026

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在健康参与者中,PDE4抑制剂穆菲米拉斯特的安全性,耐受性和药理动力学:首次对人类进行第一阶段研究

Xiuqi Li1, Xiaofei Wu1, Aihong Huo2

  • 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Clinical pharmacology in drug development
|January 16, 2026
PubMed
概括

穆菲米拉斯特是一种新型的固酶4 (PDE4) 抑制剂,在健康成年人中显示出安全和线性药理动力学. 需要进一步的研究来评估它对炎症性疾病的疗效.

关键词:
食物的影响,mufemilast.药物动力学 药物动力学在安全方面,安全是安全的.可以容忍的耐受性.

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