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Updated: Jan 18, 2026

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在胰腺癌中,垂直RAS通路的抑制驱动了可用于治疗的线粒体变化

Philipp Hafner1,2, Steffen J Keller1,2, Xun Chen1,3

  • 1Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Signal transduction and targeted therapy
|January 16, 2026
PubMed
概括

胰腺癌中双重SHP2/MEK1/2抑制导致线粒体变化和铁亡的脆弱性. 将其与GPX4抑制相结合,抑制了瘤生长,为KRAS突变的PDAC提供了一个新的治疗策略.

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