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Updated: Jan 18, 2026

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
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通过mRNA-脂质纳米粒子疫苗进行最佳的小鼠CD4+T细胞原始化需要内源抗原处理

Julia E Rood1, Suh Kyung Yoon2,3, Mary K Heard4,5

  • 1Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ROODJ@chop.edu.

Nature communications
|January 16, 2026
PubMed
概括

使者RNA (mRNA) 疫苗通过在抗原呈现细胞 (APC) 内的内部抗原呈现来激活CD4+ T细胞,而不是通过外部吸收来激活. 这种内源抗原呈现对于有效的mRNA疫苗免疫力至关重要.

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