在快速生长的真菌细菌中,由于含有erm((55) 的塑体,导致了广泛的化物耐药性
Christopher I Graham1, Barbara A Brown-Elliott2, Bibiana Gonzalez-Ramirez2
1Cadham Provincial Laboratory, Diagnostic Services, Shared Health, Winnipeg, MB, Canada.
Scientific reports
|January 16, 2026
概括
一个新的等离子体编码基因, erm(55),在快速生长的真菌菌体 (RGM) 中赋予了宏化物耐药性. 这些乱交的等离子体正在RGM物种中传播,对抗微生物治疗的有效性构成重大威胁.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 宏酸对于治疗快速生长的真菌菌菌 (RGM) 感染至关重要.
- 在RGM中,宏类耐药性通常与23SrRNA或染色体ERM基因的突变有关.
- 一个新的塑体编码的erm(55) 基因此前已被确定为Mycobacterium chelonae.的宏化物耐药性的原因.
研究的目的:
- 调查有色素RGM物种中含有erm(55) 质粒的流行率和遗传多样性.
- 了解这种新型抵抗机制的传播和影响.
主要方法:
- 来自美国参考实验室 (1997-2024) 的临床分离物的查.
- 来自六种不同的RGM物种的30 erm(55) 含有质粒的遗传特征.
- 对等离子体骨干的分析,尺寸变化和额外抗性基因的存在.
主要成果:
- 在6种RGM物种中确定了30个含有erm55) 的质粒.
- 质粒共享一个共同的126kb的骨干,但由于插入/删除,其大小 (119-173kb) 不同.
- 六个等离子体也携带重金属阻力运算子,表明高杂乱性.
结论:
- 含有erm(55) 的等离子体具有高度的乱交和结合性,在几十年内不被注意地传播.
- 这些等离子体存在于M. chelonae和各种致病性色素RGM物种中.
- 继续将erm(55) 传播到其他RGM物种是不可避免的,对宏类药物治疗有严重的影响.
更多相关视频
10:41The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
Published on: January 13, 2013
19.0K
12:32Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach
Published on: December 14, 2019
14.6K
相关概念视频
01:30Development of Antibiotic Resistance
1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
00:57Antibiotic Selection
59.4K
Overview
59.4K
00:46Genomic DNA in Prokaryotes
48.3K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.3K
01:28Plasmids
1.2K
Plasmids are extrachromosomal DNA molecules found in bacteria, archaea, and some eukaryotic microbes like yeast. These small, circular DNA structures typically contain fewer than 30 genes, although some may exist linearly. Plasmids vary in their number within a cell, known as copy number. Single-copy plasmids are present in one copy per cell and multi-copy plasmids are present in multiple copies, reaching over 100 copies per cell.Plasmids usually replicate independently of the chromosomal DNA...
1.2K
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
01:23Stringent Response in E. coli
300
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
300