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端粒长度和相关基因多态性在信号通路对精液质量的影响

Xueshan Jia¹, Jinhu Cao², Shengnan Zhang¹

¹School of Public Health, Zhengzhou University, 450001, Zhengzhou, China.

Scientific reports

|January 16, 2026

概括

精子端粒长度 (STL) 与精子度和数量有非线性关系,可能作为精液质量的可靠生物标志物. 端粒通路基因 (POT1,TERT) 的基因变异与改变的STL和精子参数有关.

科学领域:

生殖生物学生殖生物学
遗传学是一个遗传学.
生物标志物发现发现

背景情况:

精液质量对男性生育能力至关重要,因为端粒长度 (STL) 和基因多态可能会影响它.
研究STL,基因变异和精液参数之间的相互作用可以揭示男性生殖健康的新见解.

研究的目的:

评估精子端粒长度 (STL) 和与端粒相关的通路基因中的基因多态性,作为精液质量的潜在生物标志物.
在一组男性志愿者中探索基因多态,STL和各种精液参数之间的关联.

主要方法:

用计算机辅助精子分析评估精液参数.
使用实时光定量PCR测量精子端粒长度 (STL).
通过聚合酶链反应检测出与端粒相关的通路基因 (POT1,TERF1,TERT) 中的基因多态性.

主要成果:

在STL和精子度 (P < 0.001) 和总精子数 (P = 0.007) 之间观察到非线性关系.
精子总数,精子度,渐进性运动率和总活力百分比的异常风险较低,与较高的STL四分位数相关.
特定的POT1和TERT基因变异与STL和各种精液参数有显著的相关性,表明有间接的调节作用.

结论:

精子端粒长度 (STL) 可以作为评估精液质量的可靠生物标志物.
端粒通路基因 (POT1,TERT) 的遗传变异与STL和精子参数显著相关.
端粒通路基因中的多态可能通过影响STL间接影响精液参数,为男性不孕症研究提供了一个新的假设.

关键词:

基因多形态的多态化缓解效应是一种缓解效应.精液参数精液参数精子端粒的长度 (STL)

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