婴儿的大脑是如何折叠的? 硫深化与硫跨度,厚度,曲率和微观结构的发展有关
Sarah S Tung1, Xiaoqian Yan2, Bella Fascendini3
1Department of Psychology, Stanford University, Stanford, CA, USA. sstung@stanford.edu.
Communications biology
|January 16, 2026
概括
早期形成的大脑在出生时更深,在出生后更慢地深化. 这项研究揭示了婴儿大脑发育中的协调性解剖学和微观结构变化,建立了规范性状发育轨迹.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 皮层折叠,特别是状发育,在产前开始,并在产后继续.
- 产后发育的精确时间表和潜在机制尚不清楚.
研究的目的:
- 纵向检查人类婴儿生命的第一年期间的脏的宏观解剖学和微观结构变化.
- 为了建立产后深化的规范性发育轨迹.
主要方法:
- 使用结构和定量磁共振成像 (MRI) 来自79个婴儿会议 (出生至1岁).
- 分析了16-31个妊娠周之间出现的硫中的宏观解剖学参数和微观结构组织密度 (纵向放松率,R1).
主要成果:
- 早期出现的硫在出生时更深,在出生后加深的速度较慢,与晚些时候出现的硫相比.
- 在第一年,硫的宽度 (42%),厚度 (21%),组织密度 (33%) 增加,度减少 (14%).
- 硫深度是由硫跨度,厚度,曲率和微观结构的组合预测的,沿硫的变化.
结论:
- 产后深化是一个不均的过程,涉及协调的解剖和微观结构变化.
- 在子宫内突突起的时间会影响产后发育模式.
- 这些发现为理解典型的婴儿大脑发育和识别非典型模式提供了规范框架.
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