解读从出生到6个月的多路多层次大脑网络连接.
Qiang Li1, Zening Fu2, Hasse Walum3,4
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA. qli27@gsu.edu.
Communications biology
|January 16, 2026
概括
在婴儿大脑中研究三重关系 (tri-FNC) 揭示了超出简单的对联连接的复杂网络相互作用. 这为早期大脑发育和发展轨迹的潜在生物标志物提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 网络科学 网络科学
背景情况:
- 了解人类大脑需要检查复杂的,非线性相互作用,而不仅仅是配对的功能连接.
- 婴儿期是大脑发育的关键时期,影响未来的学习和健康.
- 现有的研究缺乏对婴儿多途径,多尺度大脑网络相互作用的调查.
研究的目的:
- 在婴儿的大脑内在连接网络 (ICNs) 之间全面调查双 (pair-FNC) 和三 (tri-FNC) 关系.
- 在早期发育过程中探索婴儿大脑中更高层次的功能关系.
- 确定三FNC是否在早期大脑成熟过程中提供了超越对FNC的洞察力.
主要方法:
- 对71名典型发育的婴儿 (4-179天) 的功能性大脑网络相互作用的分析.
- 在内在连接网络 (ICNs) 之间对对 (对-FNC) 和三重 (tri-FNC) 关系的全面调查.
- 专注于在生命的前六个月期间扫描的婴儿的数据.
主要成果:
- 在婴儿大脑中发现了显著的层次,多途径和多尺度大脑功能网络相互作用.
- 三重功能网络连接 (tri-FNC) 揭示了在早期开发过程中并未通过对式交互 (pair-FNC) 捕获的洞察力.
- 识别的三FNC主要涉及默认模式,传感器,视觉,边缘,语言,突出和中央执行网络,与三重网络模型保持一致.
结论:
- 大脑的网络系统,包括三重网络模型组件,可能在婴儿期的前六个月内建立.
- 与双FNC相比,三重功能网络连接 (tri-FNC) 为高阶非线性相互作用提供了额外的洞察力.
- 探索tri-FNC可以产生更可靠的生物标志物来描述婴儿大脑发育轨迹.
更多相关视频
11:14A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
Published on: October 4, 2015
11.4K
09:44Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
Published on: March 8, 2024
5.8K
相关概念视频
Neural Circuits
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Spinal Cord: Information Processing
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Parallel Processing
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
Storage
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze each...
