克罗恩病和性结肠炎中共享和独特的自发大脑活动模式:基于皮质表面分析的证据
Mengting Huang1,2,3, Qinyue Luo1,2,3, Shuo Huang1,2,3
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
炎症性肠道疾病 (IBD) 患者表现出常见的感觉运动大脑变化,克罗恩病 (CD) 和性结肠炎 (UC) 具有明显的模式. 神经成像揭示了这些IBD亚型的独特的大脑肠道通路.
科学领域:
- 神经成像是一种神经成像.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),与情绪障碍有关.
- 在CD和UC之间共享和区别的潜在神经生物学机制在很大程度上是未知的.
研究的目的:
- 在CD和UC患者中使用休息状态功能性MRI (rs-fMRI) 调查自发神经活动的共享和独特模式.
- 识别神经成像标记物,以了解IBD亚型中的脑肠病理生理学.
主要方法:
- 采用了rs-fMRI数据的皮质表面分析.
- 低频波动幅度 (ALFF) 和区域同质性 (ReHo) 在248名IBD患者 (180名CD,68名UC) 和190名健康对照 (HC) 中进行了测量.
- 对灰质体积进行控制的分析,以及人口,临床和神经心理学数据与神经活动相关.
主要成果:
- 与HC相比,CD和UC患者在体感和运动皮层中呈现出减少的ALFF和ReHo.
- 癌症患者在侧面皮表现出较低的ReHo,而UC患者在中部皮和上顶皮区域表现出较高的ReHo.
- 在CD中,运动皮层活动与全身症状和情绪功能相关;在UC中,它与体化相关.
结论:
- 在IBD中存在感官运动功能障碍的常见神经特征.
- 对于CD和UC确定了不同的皮质模式,表明亚型特定的脑肠病理生理学.
- 神经成像为IBD的机制性见解和患者分层提供了潜在的潜力.
更多相关视频
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
07:29Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
相关概念视频
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Introduction
Inflammatory Bowel Disease III: Crohn's Disease
Inflammatory Bowel Disease IV: Clinical Manifestations
