探索汉族和非汉族人口之间人类肠道微生物组的差异
Jingjing Wang1, Zhenmiao Zhang1, Yang Chen2
1Department of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Genome biology
|January 16, 2026
概括
地理显著影响人类肠道微生物群,影响汉族和非汉族人群之间的微生物丰富性和单核酸多态性 (SNP). 这项研究探讨了这些特定于种群的基因组变异.
科学领域:
- 微生物组研究 微生物组研究
- 基因组学就是基因组学.
- 人口研究 人口研究
背景情况:
- 人类肠道微生物群因地理位置,饮食和生活方式而在不同的人群中存在显著差异.
- 以前的研究集中在微生物丰富度上,忽视了单核酸多态 (SNP) 在人群特异性差异中的作用.
研究的目的:
- 系统地调查汉族和非汉族人口之间的肠道微生物差异,包括SNP.
- 确定特定于种群的微生物基因组集群及其功能影响.
主要方法:
- 使用了人类肠道微生物群参考基因组目录 (HGMRGC).
- 分析了微生物丰富度和SNP数据.
- 进行了β和α多样性分析.
主要成果:
- 地理是微生物丰富度和SNP变化的主要驱动因素.
- 在Collinsella中确定了689个具有功能差异的种群特定基因组集群.
- 发现了108种与维生素生物合成,抗生素耐药性和碳水化合物代谢相关的明显流行.
- 观察到微生物丰富度和SNP的显著种群间差异.
- 非中国人群表现出更高的微生物丰富多样性;汉族人群表现出更大的SNP多样性.
结论:
- 特定种群的特征极大地影响肠道微生物的多样性和功能.
- 建立了一个全面的人类肠道微生物参考基因组目录,强调汉族中国人群.
- 为未来关于肠道微生物群基因组变异的研究提供了基础.
相关概念视频
Anatomy of the Intestines
86.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.8K
What is Monogastric Digestion?
75.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.0K
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K


