由A组链球菌引起的外周感染:一个病例系列
Michaela Tinggaard1, Thor Bech Johannesen2, Steen Hoffmann3
1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. michaela.tinggaard@regionh.dk.
BMC infectious diseases
|January 16, 2026
概括
甲组链球菌 (GAS) 周围耳道感染,包括死软组织感染 (NSTI),在流行后急剧增加. M1克隆导致严重的病例,通常没有易感因素,导致显著的发病率和死亡率.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19大流行,全球范围内观察到A组链球菌 (GAS) 感染的增加.
- 周围周围的感染,包括死软组织感染 (NSTI),是严重的GAS表现,需要及时识别和管理.
研究的目的:
- 在14个月的时间内,在一个机构审查周围轨道气体感染病例,包括NSTI.
- 确定这些感染的临床特征,致病菌株和结果.
主要方法:
- 在哥本哈根大学医院Rigshospitalet进行了一系列回顾病例.
- 包括成年患者,怀疑患有外围轨道NSTI和培养确认的GAS.
- 分析了人口统计,临床表现,诊断结果,治疗和结果的数据.
主要成果:
- 确定了11例围绕轨道气体感染病例,平均年龄为72岁.
- 四名患者患有糖尿病,一名患者曾经接受过眼手术;大多数患者缺乏其他危险因素.
- 严重的结局包括败血症休克 (2例),死亡 (1例) 和视力敏度永久性降低 (2例).
- 在五个侵入性病例中确定了M1克隆 (MLST28 / emm1.0).
结论:
- 观察到严重的外围轨道气体感染的累积,包括NSTI,主要是由M1克隆引起的.
- 许多患者缺乏侵入性GAS疾病的典型风险因素,突出显示了对临床怀疑的必要性.
- 积极的治疗包括抗生素,手术除和支持性护理对于管理这些可能危及生命的感染至关重要.
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