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NIR-II-激发型I结合聚合物光敏感剂用于癌症光动力学疗法

Yufu Tang¹, Chunxu He², Cheng Chen¹

¹Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.

Advanced materials (Deerfield Beach, Fla.)

|January 17, 2026

概括

研究人员开发了由近红外II (NIR-II) 光激活的新型有机I型光敏感剂 (PSs),用于增强光动力学治疗 (PDT). 这些由NIR-II激发的PS能有效地产生反应性氧物种 (ROS),用于以更深的光透治疗低氧瘤.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
摄影化学的使用.

背景情况:

第一种类型的光动力学疗法 (PDT) 对缺氧瘤具有前景,近红外II (NIR-II) 刺激提供了优异的组织透.
现有的NIR-II光敏化剂 (PSs) 通常是NIR-I激发的,而NIR-II激发的I型PSs通常会受到低反应性氧物种 (ROS) 产量的影响.
开发高效的NIR-II激发型I型PS以通过NIR-II光直接激活仍然是一个重大挑战.

研究的目的:

设计和合成由NIR-II光直接激活的高效的有机I型光敏感剂 (PSs).
调查在捐赠-接受系统中使用通过空间电荷转移 (CT) 来创建NIR-II激发的I型PS的一般策略.
评估这些新型PSs治疗缺氧固体瘤的疗效.

主要方法:

合成PNT-PFT纳米颗粒 (NP),其中包括链接的捐赠者-接受者对,以诱导穿越空间的电荷转移 (CT).
描述PNT-PFTNP的NIR-II吸收特性和ROS生成效率.
在4T1小鼠模型中瘤抑制的体内评估,使用1064nm NIR-II辐射.

主要成果:

由于通过空间CT,PNT-PFT NP表现出红移和放大NIR-II吸收.
设计的捐赠者-接受器能量对齐促进了电子流动,增强了从氧气中产生ROS的能量.
在低功率1064nm辐射下,PNT-PFTNP在4T1模型中实现了89.3%的瘤抑制,证明了高治疗效率.

结论:

成功建立了一个设计高效的NIR-II激发型I型PS的总体策略,该策略基于链接的捐赠者-接受者对中的透过空间CT.
PNT-PFTNP显示出通过NIR-II激活的I型PDT治疗缺氧固体瘤的巨大潜力.
这项工作为先进的I型光敏感器的设计原则提供了有价值的机械洞察力.

关键词:

在NIR-II中激发光敏剂的光敏化剂.链接的捐赠者接受者通过空间传输收费.第一种类型的光敏感剂.

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