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增强的升级转换发光纳米载体,用于有效的瘤向光动力疗法,与免疫疗法相结合

Jongseon Choi¹, Hyoung Soo Yuh², Byung Young Park²

¹Graduate School of Energy Science and Technology, Chungnam National University, Daejeon, South Korea.

Advanced healthcare materials

|January 17, 2026

概括

这项研究开发了结合光动力学疗法 (PDT) 和免疫疗法的新型纳米粒子载体. 增强的纳米载体有效地向癌细胞,增强治疗效果,并改善抗瘤免疫反应.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
在瘤学瘤学.

背景情况:

结合性癌症治疗比单一疗法提供了更高的疗效.
光动力疗法 (PDT) 和免疫疗法是有前途的癌症治疗方法.
现有的PDT方法面临着有限的组织透和低反应性氧物种 (ROS) 生产的挑战.

研究的目的:

开发基于近红外 (NIR) 诱导的多上转换纳米粒子 (MUN) 的纳米载体 (FMUN3-Ce6 / IND) 用于联合PDT和免疫治疗.
通过改善上转换发光和ROS生成,提高PDT的有效性.
评估将PDT与因多克西莫德 (IND) 介导免疫疗法结合的协同抗瘤效应.

主要方法:

合成多上转化纳米粒子 (MUNs) 与e6 (Ce6) 和印克西莫德 (IND) 共同加载.
叶酸配体的结合用于活性瘤向.
在体外和体内对ROS生成,癌细胞中的光毒性和免疫细胞调节 (CD3 +,CD8 +,CD4 +,FoxP3 +) 的评估.

主要成果:

MUNs的红色排放量增加了519倍,显著增强了PDT.
FMUN3-Ce6/IND纳米载体的ROS生成率高于自由Ce6.6的18倍.
通过叶酸进行主动向改善了叶酸受体过度表达细胞中的光毒性.
加入IND增加了CD8+/Treg细胞比率约5.4倍,表明增强了抗瘤免疫力.
在体内证明了协同作用的抗瘤疗效.

结论:

基于MUN的多纳米载体为协同癌症治疗提供了一个强大的平台.
这种方法克服了传统PDT和IDO抑制剂单疗的局限性.
开发的纳米载体通过结合向PDT和免疫疗法,有望改善癌症治疗结果.

关键词:

组合疗法治疗组合治疗.免疫疗法免疫疗法光动力学疗法是一种光动力学疗法.有针对性的药物输送.上升转换纳米粒子

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