用混合建模方法对固定间隔的意志性叹息协议剖析心血管反应
Neel Muzumdar1, Kelly Sun1, Samuel Zhang1
1Department of Kinesiology and Health, Rutgers University-New Brunswick, New Brunswick, New Jersey, USA.
Psychophysiology
|January 17, 2026
概括
随意叹息,使用固定间隔的随意叹息 (FIVS) 协议,可靠地激活了交感神经系统和心血管反应. 这种可访问的方法可以作为一种新的压力测试,用于检测心血管功能障碍的早期迹象.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 呼吸系统调节 呼吸系统调节
背景情况:
- 叹息引起了同情心血管反应,类似于运动.
- 这种反应有可能用于分级应力测试,以确定临床前心血管变化.
- 目前评估心血管应激反应的方法可能不是普遍可用的或对早期功能障碍敏感.
研究的目的:
- 引入和验证用于心血管应力测试的固定间隔意志叹息 (FIVS) 协议.
- 在不同叹息频率下对FIVS进行心血管和自主反应的特征.
- 探索对FIVS协议的反应中的基于性别的差异.
主要方法:
- 开发了固定间隔的意志性叹息 (FIVS) 协议,每30秒和15秒间隔发出节奏叹息.
- 招募250名健康的大学生 (65%为女性) 进行基线和FIVS任务.
- 连续测量心率 (HR),血压和呼吸,使用混合模型分析反应.
主要成果:
- FIVS显著增加了HR,低频心率变化 (LF-HRV),脉冲过渡时间变化 (PTTv),平均动脉压 (MAP) 和低频血压变化 (LF-BPV).
- 响应在更短的叹息间隔 (15s vs. 30s) 中更为明显,这表明剂量依赖的效果.
- 与女性相比,男性的同情指数 (HR,LF-HRV,LF-BPV,PTTv) 增加得更大,而女性的高频HRV (HF-HRV) 减少较小.
结论:
- 通过FIVS协议,意志性叹息有效诱导同情激活和心血管变化.
- 根据FIVS协议,根据叹息的频率和强度,可以显示分级的反应.
- 检测到的性别差异表明FIVS可以识别心血管反应的个体变异,可能作为早期功能障碍检测的可访问的压力测试.
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