孤立的单一动脉与神经发育障碍之间的关联:基于人口的研究
C Ebbing1,2, A Halmoy3,4, E Jauniaux5
1Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
概括
孤立单动脉 (iSUA) 与智力障碍 (ID) 和多动症 (ADHD) 有很弱的联系,特别是在女性中. 过早分娩和SGA中介不到10%的这种关联,为父母提供安慰.
科学领域:
- 围产儿医学 围产儿医学
- 神经发育儿科 神经发育儿科
- 医疗信息学 医疗信息学
背景情况:
- 单动脉 (SUA) 与不良的围产期结果和重大异常有关.
- 有限的数据存在于SUA和儿童神经发育障碍 (NDD) 之间的关联.
- 孤立的SUA (iSUA) 需要进一步调查NDD风险和介导因素.
研究的目的:
- 为了评估NDD的风险在儿童与孤立的SUA (iSUA).
- 评估性对iSUA-NDD协会的影响.
- 检查怀孕年龄和出生体重在iSUA-NDD关系中的调解作用.
主要方法:
- 历史性的国家队列研究,将挪威登记册 (1999-2013年出生) 联系起来.
- 包括被诊断患有iSUA的单个活生生的婴儿.
- 对NDD,早产和SGA进行多层次逻辑回归和因果调解分析.
主要成果:
- iSUA与智力障碍 (ID) 和ADHD的几率增加有关.
- 在女性中观察到关联,但在男性中没有.
- 过早出生和小至孕年龄 (SGA) 介导了<10%的iSUA-ID关联.
结论:
- iSUA显示了与ID和ADHD的弱相关性,而不是其他NDD.
- 性行为影响了iSUA-NDD协会.
- 这些发现对与iSUA相关的胎儿的家长进行咨询是令人放心的.
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