根据狗头骨形态学定义正常垂体腺和垂体巨瘤大小的变化
Hannah V Pham1, Kelsey D Brust2, Jessica A Lawrence2
1Veterinary Medical Teaching Hospital, University of California Davis School of Veterinary Medicine, Davis, California, USA.
概括
一项新的研究使用计算机断层扫描 (CT) 扫描重新定义了犬类垂体巨瘤. 研究结果表明需要特定于品种的尺寸标准,因为许多瘤比以前使用的1厘米值更小.
科学领域:
- 兽医辐射学 兽医辐射学
- 狗内分泌学 狗内分泌学
- 比較瘤學 的相關搜尋
背景情况:
- 计算机断层扫描 (CT) 对于诊断狗体下垂体巨瘤至关重要.
- 目前的诊断标准 (>1厘米直径) 基于人类的定义,不考虑狗头骨形态.
- 这导致了潜在的错误诊断下垂体巨瘤在狗由于品种特定的变化.
研究的目的:
- 为了建立标准化成像定义犬类垂体巨瘤.
- 为了研究头骨形态和正常/异常垂体腺大小之间的关系.
- 为了确定犬类垂体巨瘤是否小于确定的1厘米值.
主要方法:
- 这是一项回顾性,病例对照性研究,比较了89只患有垂体巨瘤的狗和89只健康的狗的CT扫描.
- 测量包括垂体腺的尺寸 (高度,长度,宽度,体积), sella turcica和大脑形态.
- 分析的重点是基于头骨形状的变化 (胸头,中脑,双脑).
主要成果:
- 21.3%的犬类垂体巨瘤的高度小于1厘米.
- 建议的诊断标准:双脑型狗脑下垂体高度>0.60厘米或体积>0.17厘米3;双脑型狗脑下垂体高度>0.65厘米或体积>0.31厘米3.
- 对于多利霍脑型狗的数据不够.
结论:
- 人类产生的1厘米的值不足以诊断犬类垂体巨瘤.
- 头骨形状显著影响 pituitary 腺体大小和巨型瘤检测.
- 特定于品种的CT成像标准对于准确诊断和治疗犬类垂体瘤是必要的.
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