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Updated: Jan 18, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

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对BRCA野生型三阴性乳腺癌的双PARP/NAMPT抑制剂:破坏同源重组修复和激活抗瘤免疫力

Kaizhen Wang1, Dexiang Wang1, Jun Tong1

  • 1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Journal of medicinal chemistry
|January 17, 2026
PubMed
概括

这项研究引入了化合物10n,一种新型的多 (ADP-ribose) 聚合酶 (PARP) 和NAMPT的双重抑制剂,通过诱导癌细胞死亡和增强免疫反应,显示出治疗BRCA野生型三阴性乳腺癌 (TNBC) 的重大前景.

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