药物相关的甲状腺眼病:一篇综述
Terence Ang1,2, Abdullah Almater3,4,5, Dinesh Selva6,3
1Discipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, SA, Australia. terencewxang@gmail.com.
概括
像阿勒姆图祖马布和免疫检查点抑制剂 (ICI) 这样的药物可以导致甲状腺眼病 (TED). 虽然常常与标准的TED相似,但一些ICI可能会导致TED类症状,而不会导致甲状腺功能障碍.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼部疾病 (TED) 是一种影响轨道的自身免疫性疾病.
- 药物诱导的甲状腺功能障碍是某些药物的已知并发症.
- 特定药物与TED的发展之间的联系需要进行系统的审查.
研究的目的:
- 系统地审查有关药物相关甲状腺眼病 (TED) 的文献.
- 为了确定涉及TED开发的药物.
- 为了比较药物相关TED与de novoTED的特征.
主要方法:
- 在PubMed,EMBASE和Web of Science的系统文献搜索,截至2025年3月31日.
- 包括描述药物相关甲状腺功能障碍和随后的TED发展的研究.
- 不包括缺乏甲状腺功能障碍或轨道病变的产品.
主要成果:
- 23项研究符合纳入标准,涉及阿姆图祖马布,免疫检查点抑制剂 (ICI),阿米奥达龙和莱纳利多米德.
- 相关的AlemtuzumabTED显示甲状腺功能障碍的平均发病时间为26.3个月,TED显示在功能障碍后的19.9个月.
- 免疫检查点抑制剂 (ICI),特别是抗CTLA-4药物,如伊皮利姆巴和特梅利姆巴,经常涉及,有时会导致无甲状腺功能障碍的轨道病变.
结论:
- 与药物相关的TED是轨道炎症状况的关键差异诊断.
- 临床和放射学特征,以及管理,通常与新的TED相似.
- 某些ICI可以呈现独特的轨道炎症表型,包括TED或"TED样"轨道病,独立于甲状腺功能障碍.
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