在阳性肉毒症中,重复神经刺激的发现与肌痛性严重性肌痛症相比较
Halit Fidancı1, Halil Can Alaydın2, Ahmet Yusuf Ertürk2
1Department of Neurology, Division of Clinical Neurophysiology, University of Health Sciences Adana City Training and Research Hospital, Yuregir, Adana, 01370, Turkey. dr.halitfidanci@gmail.com.
概括
重复性神经刺激 (RNS) 可以帮助区分阳性肉毒 (IB) 和肌痛性骨髓灰质炎 (MG). 与MG相比,IB显示了较低的神经幅度和明显的RNS模式.
科学领域:
- 神经学 神经学
- 神经生理学 神经生理学
- 毒理学 毒理学 毒理学
背景情况:
- 毒素的使用正在增加,导致更多的并发症,如阳性毒素 (IB).
- 区分IB与其他神经肌肉疾病,如肌痛性肌痛症 (MG),对于准确的诊断和治疗至关重要.
- 重复神经刺激 (RNS) 是评估神经肌肉结合障碍的关键神经生理学工具.
研究的目的:
- 调查和比较反复神经刺激 (RNS) 的发现,在患有阳性肉毒 (IB) 和骨髓灰质炎 (MG) 的患者中.
- 确定特定的RNS参数,可以帮助区分IB和MG.
主要方法:
- 从IB和MG患者的临床和神经生理学数据的回顾性审查.
- 在部,面部和脊柱辅助神经上以各种频率 (2,3,5和50赫兹) 进行RNS.
- 两组之间的复合肌肉动作潜力 (CMAP) 幅度和反应模式的比较.
主要成果:
- 与MG患者相比,Iatrogenic肉毒症患者表现出下和面部神经CMAP幅度的较低.
- 在低频RNS期间,IB患者的60%和MG患者的17%观察到逐渐下降.
- 高频 (50 Hz) 部神经刺激在IB患者中显示出更大的幅度变化和增加,有些人超过100%.
结论:
- 降低的CMAP振幅,高频增量响应和低频逐渐下降是IB的更多特征.
- 患有MG的患者在低频RNS上表现出U形模式,并且最初的减少更为明显.
- RNS的研究结果提供了有价值的区分特征,用于鉴定出产性肉毒和严重骨髓灰质炎.
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