血清利波卡林-2的诊断价值在患有炎症性肠道疾病的埃及患者中:一个病例对照研究
Mina W N Abd El Malak1, Noha A El Nakeeb1, Mohamed A Abo Daif2
1Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
The Egyptian journal of immunology
|January 17, 2026
概括
血清利波卡林-2 (LCN-2) 在埃及患者的炎症性肠病 (IBD) 中显示出出色的诊断效用. 虽然在IBD中升高,但LCN-2不能区分性结肠炎和克罗恩病,也不能表明疾病的活性.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 临床生物化学 临床生物化学
- 生物标志物发现发现
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),带来了诊断挑战.
- 利波卡林-2 (LCN-2) 是肠道炎症的潜在生物标志物,需要进一步的临床评估.
研究的目的:
- 评估血清Lipocalin-2 (LCN-2) 在被诊断为IBD的埃及患者的诊断和临床效用.
- 评估LCN-2区分UC和CD的能力,并与疾病活动和持续时间相关联.
主要方法:
- 一项涉及30名IBD患者 (18名UC,12名CD) 和30名健康对照者的病例控制研究.
- 血清LCN-2水平通过酶相关免疫吸收试验 (ELISA) 测量.
- 使用特鲁洛夫和维茨的标准 (UC) 和哈维-布拉德肖指数 (CD) 评估疾病活动;用于诊断实用性的ROC曲线分析.
主要成果:
- 与对照组相比,IBD患者的血清LCN-2水平显著更高 (p < 0.001).
- ROC分析表明,在IBD检测中,LCN-2具有很好的诊断效用 (AUC = 0.980).
- 在UC和CD之间,LCN-2水平没有显著差异,也没有与疾病活性相关,但与疾病持续时间和血小板数量有正相关.
结论:
- 血清LCN-2在研究的埃及人群中证明了在识别IBD方面具有高的诊断准确性.
- LCN-2缺乏区分UC和CD或评估当前疾病活动的歧视力.
- LCN-2与疾病持续时间的相关性表明它作为慢性炎症的标志物而不是急性严重性的标志物.
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