微细和超细颗粒物成分和自闭症谱系障碍 (ASD)
Amanda J Goodrich1, Deborah H Bennett1, Michael J Kleeman2
1Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Environment international
|January 17, 2026
概括
早期暴露于铁和等特定的超细颗粒物 (PM0.1) 成分与增加自闭症谱系障碍 (ASD) 风险有关. 这些发现强调了粒子组成和时间在ASD发展中的重要性.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 暴露于颗粒物 (PM) 是自闭症谱系障碍 (ASD) 的已知危险因素.
- 对于超细颗粒 (PM0.1) 成分在ASD病因学中的特定作用的了解有限.
- 之前的研究集中在总PM2.5质量上,忽视了尺寸特定的组件.
研究的目的:
- 调查产前和早期暴露于尺寸解析的PM组件和ASD之间的关联.
- 分析与ASD风险相关的特定PM0.1和PM2.5组件.
- 检查暴露时间 (产前与生命第一年) 对ASD发展的影响.
主要方法:
- 来自CHARGE研究的1281名儿童 (751名自闭症,530名对照) 的分析.
- 使用带偏差校正的化学运输模型估计每日PM0.1和PM2.5成分度.
- 逻辑回归模型用于估计每四分位数范围 (IQR) 的ASD几率比率 (ORs),增加PM组件,调整混因子.
主要成果:
- 暴露于PM0.1铁,,黑碳和的第一年暴露显示出与增加ASD几率 (ORs从1.27到1.92) 的一致关联.
- 接触PM0.1-2.5铁和的第一年暴露也与更高的ASD几率相关 (OR分别为1.54和1.46).
- 与产前暴露相比,第一年暴露的相关性更强.
结论:
- 特定的颗粒物成分,特别是超细分数 (PM0.1),在生命早期有助于ASD风险.
- 暴露时间至关重要,第一年暴露显示出比产前暴露更强烈的关联.
- 颗粒的组成和大小是理解环境对ASD的贡献的重要因素.
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