无二氧化薄膜涂层水化和平板电脑核心相互作用的太赫兹成像
Mingrui Ma1, Marwa Nassar2, Jason Teckoe2
1Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.
International journal of pharmaceutics
|January 17, 2026
概括
制药商正在探索无二氧化 (TiO2) 的平板电脑涂层. 特拉赫兹脉冲成像显示,像碳酸这样的替代涂层不会影响片的分解,为薄膜涂层提供了可行的选择.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 是一种材料科学.
- 分析化学是一种分析化学.
背景情况:
- 由于欧盟对二氧化 (TiO2) 的限制,制药薄膜涂层中需要替代品.
- TiO2是即时释放药片配方中常见的白色变暗剂.
- 开发无二氧化涂料对于产品的持续制造至关重要.
研究的目的:
- 为了评估没有TiO2的平板电脑涂层的水化和分解.
- 为了研究替代化剂,如碳酸 (CaCO3) 对涂层性能的影响.
- 评估不同薄膜涂层材料 (聚乙醇 - PVA,基基纤维素 - HPMC) 对药片水化的影响.
主要方法:
- 使用特拉赫兹脉冲成像 (TPI) 来非侵入性地检查片涂层的水分.
- 分析了带有TiO2无涂层 (带有或没有CaCO3) 的即时释放片剂配方.
- 使用PVA或HPMC的涂层,大约厚度为100μm.
主要成果:
- TPI发现,薄膜涂层的类型显著影响水化和光散射特性.
- 没有证据表明无TiO2涂层会对药片分解产生负面影响.
- 带有HPMC和CaCO3涂层的药片在水化时表现出凝,但在可接受的时间框架内实现了完全水化.
结论:
- 替代不透明剂和薄膜涂层材料可以成功地应用于制药配方中.
- 没有TiO2的涂层似乎不会影响平板电脑分解的关键性能属性.
- 该研究为选择和开发新的制药薄膜涂层提供了有价值的机械见解.
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