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肖柴胡可以通过调节肠道微生物群-大脑轴来缓解老鼠慢性压力诱导的抑郁行为

Xiangwei Zhao¹, Jing Liang², Ting Zhou²

¹School of Psychology and Mental Health, Hebei Key Laboratory of Mental Health and Brain Science, Tangshan Key Laboratory of Mental Health and Cognitive Neuroscience, North China University of Science and Technology, 21 Bohai Road, Tang'shan 063210, Hebei Province, PR China; Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, 21 Bohai Road, Tang'shan 063210, Hebei Province, PR China; Department of Stress Disorder Treatment,The 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, PR China.

Behavioural brain research

|January 17, 2026

概括

肖柴胡 (Xiaochaihu Decoction,XCHD) 通过改善神经可塑性和减少炎症,可以缓解小鼠的抑郁症症状. 这种传统中医药也对肠道微生物群-大脑轴产生积极影响,具有作为抗抑郁药物治疗的潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
微生物学微生物学

背景情况:

肖柴胡 (Xiaochaihu Decoction,XCHD) 对神经系统疾病有很大的前景,但其抗抑郁机制尚未完全理解.
抑郁症是一种复杂的疾病,具有多因素的起源.

研究的目的:

为了研究XCHD在缓解慢性不可预测轻度压力 (CUMS) 的小鼠模型中缓解抑郁症类行为的有效性.
阐明XCHD抗抑郁作用的潜在机制,重点关注神经可塑性,炎症和肠道微生物群.

主要方法:

建立一个CUMS鼠标模型.
行为评估包括糖糖偏好和开放场测试.
分析海马神经可塑性,炎症标志物和肠道微生物群组成,通过西式斑点,免疫光和16SrRNA测序.

主要成果:

在受压力的小鼠中,XCHD治疗显著改善了糖消耗,空间学习和记忆.
施用XCHD恢复了海马神经可塑性,减少了神经炎症,并调节了Nogo-A/S1P2R-Gαq-PKC通路.
XCHD增强了结肠紧结蛋白和重新平衡了肠道微生物群,增加了有益的Firmicutes,减少了有害的Bacteroid和Proteobacteria.

结论:

通过积极调节肠道微生物群-大脑轴,增强神经可塑性和减少炎症,XCHD可以改善类似抑郁症的症状.
这些发现表明,XCHD具有作为新型抗抑郁药治疗剂的潜力.

关键词:

慢性不可预测的轻度压力类似于抑郁症的行为我们的肠道微生物群.炎症炎症是一种炎症.神经可塑性神经可塑性这是Nogo-A/S1P2R信号.

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