3'-Sialyllactose通过塑造独特的肠道微生物群和代谢物组成来改善与抗生素相关的腹
Yi Shan1, Xiaolin Huang2, Xue Han3
1School of Food Engineering, Harbin University, Harbin 150086, China.
3'-Sialyllactose (3'-SL) 通过改善肠道微生物群和屏障功能,有效治疗与抗生素相关的腹. 这种益生菌增强有益细菌,减少炎症,提供一种自然的治疗方法.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 3 - 酸乳糖 (3 - SL) 是一种具有已知的益生菌性质的天然牛奶寡糖.
- 3 -SL缓解抗生素相关腹的确切机制尚未完全理解.
研究的目的:
- 在与抗生素相关的腹的小鼠模型中研究3 -SL的治疗作用和潜在机制.
- 分析3-SL对肠道微生物群,代谢物概况,肠道屏障功能和炎症的影响.
主要方法:
- 使用安培和新菌素建立了与抗生素相关的腹模型.
- 给予3 -SL并评估了腹表型,体重和肠道水含量.
- 分析了血清细胞因子水平,肠道透性标记物 (ZO-1,ocludin,MUC2),肠道微生物群组成 (16S rRNA测序) 和代谢物概况 (代谢学).
主要成果:
- 3 -SL治疗显著减少了腹,改善了体重,并使便中的水含量正常化.
- 3 -SL降低了促炎性细胞因子 (IL-6,TNF-α,IL-1β) 和增加了抗炎性细胞因子 (IL-10).
- 通过对ZO-1,奥克卢丁和MUC2表达的上调来增强肠道屏障功能.
- 调节肠道微生物群,增加有益的细菌,如Akkermansia和Bacteroides,同时减少Alloprevotella.
- 改变了肠道代谢,丰富了参与核酸和碳水化合物代谢的途径.
结论:
- 3 -SL显示了抗生素相关腹的显著治疗潜力.
- 这些有益的效果通过调节肠道微生物群组成和代谢途径来实现.
- 3 -SL加强肠道屏障并减少炎症,突出其作为益生菌干预的作用.
更多相关视频
08:34Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
12:58A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
相关概念视频
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs for Treatment of Constipation-Predominant IBS
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
