骨质细胞对体外治疗索莱德酸的反应:系统性审查
Maria Florez-Martin1, Adriana-Monica Radu1, Kaveh Shakib1
1Division of Surgery & Interventional Science, University College London, 9th Floor Royal Free Hospital, London, NW3 2QG, UK.
Bone
|January 17, 2026
概括
索莱德酸盐 (ZOL) 在体外直接抑制骨质母细胞,在10μM时出现负面影响. 较高的水平和较短的暴露时间可能会减轻这些影响,这对于理解骨疾病治疗至关重要.
科学领域:
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
背景情况:
- 索莱德酸盐 (ZOL) 是一种含有的双酸盐 (BP),用于治疗骨质疏松症和骨转移.
- 虽然ZOL抑制骨质细胞,但它对骨质细胞的直接影响需要进一步研究.
- 了解ZOL对骨质母细胞的影响对于准确的体外建模和开发骨再生策略至关重要.
研究的目的:
- 系统地审查对ZOL的骨质母细胞反应的体外研究.
- 评估ZOL对骨质细胞功能的剂量和时间依赖的影响.
- 为改善骨疾病的体外模型和再生方法提供信息.
主要方法:
- 按照PRISMA指南进行体外研究的系统审查.
- 搜索了 Web of Science 和 Scopus,包括 606 个记录中的 77 项研究.
- 提取了关于增殖,代谢活性,亡,ALP,生物矿物化,原蛋白合成和血管生成的数据.
主要成果:
- 不良的骨质细胞效应 (活动/增殖减少,亡增加) 发生在ZOL的中位数为10μM时.
- 在0.75μM时观察到有益效果,在1μM时没有效果;理想的纳米分子结果不一致.
- 性酸酶和生物矿物化受到剂量依赖的损害;原蛋白合成不受影响. 较高的介质保护免受负面影响.
结论:
- 佐勒多酸在体外对骨质母细胞产生直接的,剂量依赖的抑制作用.
- 骨质细胞对ZOL的反应受暴露时间和介质组成的影响.
- 本综述为建模与药物相关的骨瘤 (MRONJ) 和测试再生疗法提供了定量数据.
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