相关实验视频

Updated: Jan 19, 2026

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.2K

抗心脏特罗波宁I胺的结构-亲和平衡:序列切断的影响

Vasilisa V Krasitskaya1, Irina A Shchugoreva2, Anastasia V Rogova2

  • 1Institute of Biophysics SB RAS, Federal Research Center KSC SB RAS, Krasnoyarsk, 660036, Russia.

International journal of biological macromolecules
|January 17, 2026
PubMed
概括

研究人员优化了DNA吸附体,以检测心脏中托罗素I (cTnI). 结构分析显示,G-四重体对稳定性和结合性至关重要,而其他元素提高了改善心脏损伤诊断的特异性.

关键词:
优化 Aptamer 结构的优化形成阿普塔默-蛋白质复合体的形成.心脏中位素 I 的心脏中位素 I它们是DNA吸收剂.在G-quadruplex中使用.分子动力学分子动力学

更多相关视频

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

11.2K
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.6K

相关概念视频

Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
6.5K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.2K