从Bambusicola thoracicus中发现和工程硫转移酶SULT1B1

Mingzhu Yan1, Qanli Zhang2, Shuyao Yang3

  • 1School of Biological Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China; National Engineering Research Center of Industrial Enzymes, National Center of Technology Innovation for Synthetic Biology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

概括

研究人员阐明了SULT1B1的结构和机制,揭示了扩大的基质结合腔. 酶工程产生了一种具有显著增强活性的变体,为药物开发和生物催化剂提供了洞察力.