在6岁之前接受血造干细胞移植的儿童的肺功能
Colette Brac de la Perrière1, Julie Mazenq2, Caroline Thumerelle3
1Service de Pneumologie, Allergologie et CRCM pédiatrique. Hôpital Universitaire Robert Debré. Universié Paris Cité. Paris, France.
概括
在6岁之前进行血造细胞干细胞移植 (HSCT) 后,大约三分之一的儿童仍然存在肺功能异常. 长期呼吸监测至关重要,即使在无症状病例中,由于可能与移植相关的肺损伤.
科学领域:
- 儿科肺病学 儿科肺病学
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 关于6岁以下儿童血造细胞干细胞移植 (HSCT) 后肺功能的数据有限.
- 这个年龄组经常被排除在呼吸功能监测协议之外.
- 了解长期肺部结果对于这个脆弱的人群来说至关重要.
研究的目的:
- 描述在6岁之前接受HSCT的儿童的长期肺功能测试 (PFT) 结果.
- 为了确定与HSCT后异常肺功能相关的因素.
- 为未来的呼吸护理指南建立基线数据.
主要方法:
- 对RESPPEDHEM队列的回顾性分析,包括在6岁之前接受HSCT的儿童.
- 肺功能测试 (PFTs) 分析了HSCT后3年多的时间.
- 使用美国胸腔学会 (ATS) /欧洲呼吸学会 (ERS) 准则来定义异常.
主要成果:
- 30% (12/40) 的儿童表现出异常的肺功能.
- 最常见的异常包括阻塞性和限制性肺部缺陷.
- 超过40%的患有肺部异常的儿童无症状.
结论:
- 大约三分之一的儿童在早期HSCT后经历了持续的肺功能异常.
- 建议进行系统的长期呼吸监测,不论临床症状如何.
- 在一半的队列中缺乏HSCT前的PFTs限制了对移植的肺部异常的最终归因.
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