Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.8K
Antibiotic Selection00:57

Antibiotic Selection

59.4K
Overview
59.4K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

913
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
913
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>Vibrio campbellii</i> encodes a distinct set of type III secretion system effectors that mediate cytotoxicity in eukaryotic host models.

bioRxiv : the preprint server for biology·2026
Same author

Cuminaldehyde potentiates antimicrobial efficacy of gentamicin and ciprofloxacin against <i>Escherichia coli</i>: a response surface methodology (RSM) based study.

3 Biotech·2026
Same author

Uracil-BX-Enabled <i>O</i>-Uracilylation to Access 5-Aryloxy Uracils via Umpolung Strategy.

The Journal of organic chemistry·2026
Same author

Combined application of Vancomycin and Levofloxacin potentiates the antimicrobial activity against MRSA: a response surface methodology-based study.

Folia microbiologica·2026
Same author

Piperine inhibits biofilm formation in co-cultures of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>.

Biofouling·2026
Same author

Design principles for topological thermoelectrics.

Reports on progress in physics. Physical Society (Great Britain)·2026

相关实验视频

Updated: Jan 19, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.3K

针对Enterococcus faecalis的抗生素-植物化学组合:使用响应表面方法来优化治疗策略.

Monikankana Dasgupta1, Alakesh Maity1, Ranojit Kumar Sarker1

  • 1Microbial Ecology Research Laboratory, Department of Biotechnology, The Neotia University, Sarisha, West Bengal, 743368, India.

Antonie van Leeuwenhoek
|January 17, 2026
PubMed
概括

这项研究表明,将抗生素与自然化合物如基和甲结合起来,可以降低治疗Enterococcus faecalis感染所需的剂量,从而提高抗微生物药物的有效性.

关键词:
E. faecalis 是一个植物.抗生素 抗生素是一种抗生素.组合性研究是一种结合性研究.植物化学品 植物化学品在 RSM RSM 中.

更多相关视频

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

27.6K
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

12.5K

相关实验视频

Last Updated: Jan 19, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.3K
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

27.6K
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

12.5K

科学领域:

  • 微生物学 微生物学
  • 药理学 药理学是指药理学的学科.
  • 自然产品 化学 化学

背景情况:

  • 肠球菌 (Enterococcus faecalis) 是医院感染的重要原因之一.
  • 在E. faecalis的抗生素耐药性构成了重大公共卫生挑战.
  • 需要新的治疗策略来对抗耐药菌株.

研究的目的:

  • 研究抗生素和植物化学品对E. faecalis. 的协同作用.
  • 为了确定万科米辛,西普罗夫洛克萨辛,蒂莫金和甲的最佳组合.
  • 评估植物化学品在提高抗生素疗效方面的潜力.

主要方法:

  • 确定抗生素和植物化学品的最小抑制度 (MIC).
  • 使用分数抑制度指数 (FICI) 评估组合效应.
  • 采用响应表面方法 (RSM) 来优化剂量方案.

主要成果:

  • 蒂莫金和甲显著降低了万科米辛和西普罗弗洛克萨辛的MIC.
  • 在抗生素和植物化学品之间观察到添加性相互作用 (FICI:0.66-1).
  • RSM准确地预测了最佳组合度 (R2:0.97-0.99).

结论:

  • 使用抗生素和植物化学品的组合疗法在治疗E. faecalis感染方面表现有前途.
  • 这种方法可以提高抗微生物药物的有效性,并可能克服耐药性.
  • 优化剂量策略对于有效的组合疗法至关重要.