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Updated: Jan 19, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
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Published on: February 17, 2017

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拷贝数变化的关联与癌症中的免疫转录组景观

Stefan Loipfinger1, Arkajyoti Bhattacharya1, Carlos G Urzúa-Traslaviña1

  • 1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

NPJ systems biology and applications
|January 17, 2026
PubMed
概括

瘤中的高拷贝数改变 (CNA) 负担阻碍了免疫疗法反应. 这项研究揭示了与CNA负担相关的免疫抑制转录模式,为提高癌症治疗疗效提供了见解.

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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