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在积极监测候选人中,型基因组前列腺评分对不良病理的增量预测值

Yu Ozawa¹, Marcio Covas Moschovas^1,2, Marco Sandri³

¹AdventHealth Global Robotics Institute, Celebration, Florida, USA.

|January 18, 2026

概括

基因组前列腺评分 (GPS) 适度提高了前列腺癌不良病理学的预测,特别是在有利的中等风险患者中. 这种基因组测试有助于在积极监测和最终治疗之间做出治疗决策.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

基因组前列腺评分 (GPS) 显示了指导前列腺癌积极监测临床决策的潜力.
对激进前列腺切除术 (RP) 中不良病理的确定的临床变量之外评估GPS的附加预测价值对于有资格接受主动监测的患者至关重要.

研究的目的:

为了评估基因组前列腺评分 (GPS) 是否提供了额外的预测价值,在激进前列腺切除术 (RP) 的不良病理,超出现有的临床变量在符合积极监测的患者.
评估带有和没有GPS的预测模型的性能.

主要方法:

对387名患有非常低至有利的中等风险前列腺癌的男性进行了回顾性分析,这些男性接受了型DX测试,随后进行了RP.
多变量逻辑回归模型被用来预测不良病理 (等级组≥3和/或≥pT3a) 结合临床变量和GPS.
使用AUC,NRI和决策曲线分析评估模型性能,并对风险分层进行单独的子组分析.

主要成果:

GPS独立预测了不良病理 (p < 0.001).
添加GPS使AUC从0.69增加到0.73 (p=0.018) 并改善了重新分类 (NRI 0.41).
在有利的中等风险子组 (ΔAUC=0.039;p=0.026) 中,GPS显著改善,但在非常低/低风险子组中没有显著改善.

结论:

基因组前列腺评分 (GPS) 适度提高前列腺癌患者接受RP的不良病理的预测,特别是在有利的中等风险组.
对于有利的中等风险患者,GPS在积极监测和最终治疗之间不确定的治疗决策中提供临床实用性.
建议选择性,风险适应的GPS应用,需要在未来的多样化队伍中进行验证.

关键词:

生物标志物生物标志物基因表达分析基因表达分析基因组分类器的基因组分类器磁共振成像技术的使用在类型上,型是型.前列腺特异性抗原密度

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