与共存阻塞性睡眠呼吸暂停和肥胖相关的美国死亡率上升,1999-2019年
Areej Javeid1, Dinesh Kumar2, Javeria Nawaz2
1Allama Iqbal Medical College, Lahore, Pakistan.
Sleep medicine
|January 18, 2026
概括
从1999年至2019年,美国成年人中阻断性睡眠呼吸暂停 (OSA) 和肥胖的死亡率相结合显著增加,特别影响非西班牙裔非洲裔美国人,65岁以上的男性和中西部农村居民.
科学领域:
- 睡眠医学 睡眠医学
- 营养科学 营养科学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和肥胖经常并存,可能会增加死亡风险.
- 虽然肥胖会使个人容易患上OSA,但OSA也可能对代谢健康产生负面影响,并导致体重增加.
- 对于患有OSA和肥胖的人来说,国家死亡率模式尚不清楚.
研究的目的:
- 分析美国成年人同时存在阻塞性睡眠呼吸暂停和肥胖的死亡率的区域和人口差异.
- 检查1999年至2019年期间该人口的死亡率趋势.
主要方法:
- 对25岁以上成年人美国死亡证明数据 (CDC WONDER数据库) 的回顾性分析.
- 使用的ICD-10代码是阻塞性睡眠呼吸暂停 (G47.3) 和肥胖 (E66).
- 计算了年龄调整的死亡率 (AAMR) 并使用Joinpoint回归来确定趋势 (APC,AAPC).
主要成果:
- 总共有60,898例死亡与存在的OSA和肥胖有关 (1999-2019),总体AAMR为1.35.
- 根据年龄调整的死亡率在整个研究期间显示出一致的上升趋势.
- 在男性,非西班牙裔非洲裔美国人,65岁以上的个人以及中西部和农村地区的居民中观察到较高的死亡率.
结论:
- 在美国,阻塞性睡眠呼吸暂停和肥胖症的死亡率正在增加,尽管死亡证明报告不足可能会影响调查结果.
- 存在显著的差异,非西班牙裔非裔美国人,老年男性和农村/中西部地区的男性死亡率更高.
- 综合监测,查计划和早期干预对于管理这种高风险人群至关重要.
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