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Updated: Jan 20, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
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发现WWZ-11-098:一种刚性和选择性的CDK6降解剂

Wanwan Zhang1, Jinfeng Wen1, Yuanyuan Wu1

  • 1Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

European journal of medicinal chemistry
|January 18, 2026
PubMed
概括

研究人员开发了一种新的CDK6降解剂,WWZ-11-098,用于血液恶性瘤. 这种化合物有效降解CDK6,阻止癌细胞增殖,并在临床前模型中显示出强大的抗瘤活性.

关键词:
这是一种CDK2/4/6抑制剂.这是一种CDK6降解剂.细胞循环的细胞周期头脑黄金是什么意思

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