在精神分裂症中萨尔科佩尼亚的患病率和多维影响:与氧化应激,功能和症状严重程度的关联
1Department of Psychiatry, University of Health Sciences Bursa Faculty of Medicine, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.
Schizophrenia research
|January 18, 2026
概括
肉症是一种肌肉消耗的疾病,在精神分裂症患者中非常普遍. 建议对身体健康和氧化应激进行早期查和干预,以改善患者的治疗结果.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 标志着肌肉质量和力量的损失的萨尔科佩尼亚,是老龄化人口日益关注的问题.
- 精神分裂症与各种身体健康并发症有关,包括代谢和心血管问题.
- 萨尔科佩尼亚,氧化应激和精神分裂症之间的相互作用仍然未被充分探索.
研究的目的:
- 为了确定成年精神分裂症患者中萨尔科佩尼亚的患病率.
- 调查萨科佩尼亚与氧化应激标志物之间的关联.
- 为了检查sarcopenia,症状严重程度,功能和精神分裂症患者的生活质量之间的关系.
主要方法:
- 198名精神分裂症患者 (18-65岁) 用EWGSOP2标准评估了他们的肉症.
- 氧化应激通过总抗氧化能力 (TAC),总氧化状态 (TOS) 和氧化应激指数 (OSI) 来衡量.
- 使用标准化心理测量工具评估了临床功能,精神症状和生活质量;多重线性回归确定了氧化应激的预测因素.
主要成果:
- 在66.6%的参与者中,肉类是普遍存在的,与较低的肌肉/骨质量,强度和速度有关.
- 麻症患者报告生活质量较差,功能得分较差,精神症状较严重.
- TAC与肌肉参数正相关,与肉症严重程度反相关;回归显示BMI,肉症标准,PANSS-总和WHOQOL-BREF预测的TAC.
结论:
- 在精神分裂症中年期的患者中,萨科佩尼亚的患病率很高,并且具有临床意义.
- 这些发现强调了需要在精神分裂症中进行标症的常规查.
- 针对身体健康和氧化应激的干预措施可能会改善精神分裂症患者的结果.
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