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Updated: Jan 20, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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在细胞表面特定检测EGF-EGFR复合体及其依赖于EGFR导向的TKI处理

Delia Sumesgutner1, Philipp Brunmayr2, Viktorija Gopko1

  • 1CD Laboratory for Next Generation CAR T Cells, Vienna, Austria; Institute of Biochemistry, Department of Natural Sciences and Sustainable Resources, BOKU University, Vienna, Austria.

Biochemical and biophysical research communications
|January 18, 2026
PubMed
概括

研究人员开发了一种新工具来检测与其连接体结合的表皮生长因子受体 (EGFR). 这种工具揭示了EGFR抑制剂可以导致EGF-EGFR复合体在癌细胞表面积累.

关键词:
这就是ActE_21的意思.皮表皮肤生长因子受体 (EGFR)结合体-EGFR复合体 结合体-EGFR复合体蛋白质工程是一种蛋白质工程.铁氨酸激酶抑制剂 (TKI) 的使用

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