设计,表征和实验室评估Eudragit涂层的含的氨基化介质性二氧化纳米颗粒,用于结肠输送
Nikhil Raut1, Manasa N1, Swornahuti Panda1
1Department of Pharmaceutics, Advanced Formulation Laboratory, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal 700054, India.
一种新型的针对结肠的药物递送系统,使用氨基化半孔纳米颗粒 (AMSN) 成功改善了性结肠炎 (UC) 治疗的基 (PTB) 递送,提高了溶解度和减少炎症.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性结肠疾病,需要长期管理.
- 固醇 (PTB) 具有抗炎和抗氧化特性,但具有不良的溶解性和胃不稳定性.
- 由于这些局限性,现有的PTB配方具有有限的临床疗效.
研究的目的:
- 开发一款针对胆固醇的胆固醇特异性药物输送系统 (PTB).
- 为了提高PTB的溶解性,稳定性和治疗性疗效,治疗性结肠炎 (UC).
- 为了克服传统PTB配方的局限性.
主要方法:
- 半孔纳米粒子 (MSN) 被表面氨基化 (AMSN) 并装载着PTB.
- 这些AMSN被涂上了Eudragit S100 (EU) 用于结肠向 (Eu-PTB-AMSN).
- 鉴定包括FT-IR,XRD,DSC,SEM,TEM,TGA和BET分析;进行了体外释放和抗炎试验 (ELISA).
主要成果:
- 成功合成具有高表面积和孔积的球形,多孔的Eu-PTB-AMSN.
- 鉴定证实了PTB封装,无形分散和氨基功能化.
- 实验室研究表明,依赖于pH值,在肠道条件下延长药物释放,并在HT-29细胞中显著减少促炎细胞因子 (TNF-α,IL-6).
结论:
- 开发的结肠特定的Eu-PTB-AMSN配方有效地解决了PTB的可溶性和稳定性问题.
- 该系统通过改善药物输送和减少全身副作用,为性结肠炎 (UC) 提供了一个有前途的治疗策略.
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