相关实验视频

Updated: Jan 20, 2026

Non-Invasive Electrical Brain Stimulation for Modulating Human Motor Neuron Activity

Non-Invasive Electrical Brain Stimulation for Modulating Human Motor Neuron Activity

Published on: August 29, 2025

通过跨骨无线电频率刺激对大脑活动和行为进行非侵入性调节

Omid Yaghmazadeh¹, Leeor Alon², Tanzil M Arefin³

¹Neuroscience Institute, School of Medicine, New York University, 435 E30th St., New York, NY 10016, USA; Department of Electrical and Computer Engineering, Boise State University, 1910 University Drive, Boise, ID 83725, USA.

Brain stimulation

|January 18, 2026

概括

这项研究介绍了跨骨射频刺激 (TRFS),一种新的非侵入性脑刺激方法. TRFS使用射频能量通过准深层脑组织来精确调节神经活动,提供潜在的治疗应用.

科学领域:

神经技术的神经技术
生物物理学的生物物理.
医疗器械医疗器械

背景情况:

非侵入性深度大脑调制仍然是一个重大挑战.
像TES,TMS和TFUS这样的现有方法在焦点,深度和头骨扭曲方面存在局限性.
无线电频率 (RF) 能量为神经调节提供有效的组织透.

研究的目的:

介绍跨骨无线电频率刺激 (TRFS) 作为一种新的非接触式神经调节技术.
研究TRFS在体内通过RF诱导的热效应调节神经活动的能力.
探索两个操作模式:原始的大脑组织和转基因 (RF遗传学) 组织.

主要方法:

开发了一种定制的945MHz射频刺激系统,用于小鼠的局部大脑加热.
在完整的大脑组织上的"原始模式"和TRPV1-过度表达区域上的"RF遗传模式"中测试了TRFS.
使用光纤光度计用GCaMP指示器记录神经活动,并使用光学温度计监测温度.

主要成果:

在原始模式下,射频刺激剂量依赖地抑制皮质膜蛋白内部神经元活动,导致ipsilateral旋转偏差.
在射频遗传模式下,射频刺激激发了TRPV1-过度表达的神经元,超过了1.5°C的值,扭转了旋转偏差.
通过针对性脑部区域的热效应,证明了双模神经调制 (抑制和激发).

结论:

TRFS通过利用射频能量深层组织透和热调节可靠性来推进神经调节.
TRFS可以抑制原始神经群体中的活动或激发遗传敏感的神经元 (RF遗传学).
TRFS是下一代非侵入性脑刺激的有希望的平台,具有潜在的治疗应用.

更多相关视频

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Published on: July 18, 2014

相关概念视频

Non-Invasive Electrical Brain Stimulation for Modulating Human Motor Neuron Activity

Non-Invasive Electrical Brain Stimulation for Modulating Human Motor Neuron Activity

Source: Curado, M. et. al., Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function. J. Vis. Exp. (2016)This video demonstrates the setup and mechanism of transcranial direct current stimulation (tDCS) for modulating human motor function. By placing the anode over the primary motor cortex and the cathode over the contralateral supraorbital area, the targeted electrical stimulation increases cortical excitability, enhancing motor neuron activity and improving...

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Non-invasive electrical brain stimulation can modulate cortical function and behavior, both for research and clinical purposes. This protocol describes different brain stimulation approaches for modulation of the human motor...

High-Definition Transcranial Direct Current Stimulation for Activation of the Target Brain Region

High-Definition Transcranial Direct Current Stimulation for Activation of the Target Brain Region

Source: Chen, W., et al. Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation. J. Vis. Exp. (2019)This video demonstrates the procedure for delivering high-definition transcranial direct current stimulation (HD-tDCS) by accurately positioning electrodes using the 10–10 system, mapping their locations with a 3D digitizer, and applying stimulation to modulate neuronal activity in a targeted brain...

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Transcranial magnetic stimulation (TMS) is a technique for non-invasively disrupting neural information processing and measuring its effect on behavior. When TMS interferes with a task, it indicates that the stimulated brain region is necessary for normal task performance, allowing one to systematically relate brain regions to cognitive...

Employing Transcranial Magnetic Stimulation in a Resource Limited Environment to Establish Brain-Behavior Relationships

Employing Transcranial Magnetic Stimulation in a Resource Limited Environment to Establish Brain-Behavior Relationships

Transcranial Magnetic Stimulation (TMS) and low-frequency TMS (lfTMS) have been demonstrated to be major contributors to brain literature. Here we highlight the methods for investigating the cortical correlates of self-deception using...

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

This protocol shows how to set up a reliable HFS method in mice. Neurons throughout the hippocampal dentate gyrus are electrically stimulated by HFS directly and indirectly in vivo. Neuronal activity and molecular signaling are examined by c-fos and Notch1 immunofluorescent staining, respectively; neurogenesis is quantified by bromodeoxyuridine labeling...