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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology08:36

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Here we present methodology for the production of a focal stroke in murine white matter by local injection of an irreversible endothelial nitric oxide synthase (eNOS) inhibitor (L-Nio). Presented are two stereotactic variations, retrograde neuronal tracing, and fresh tissue labeling and dissection that expand the potential applications of this...
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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
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Diffusion tensor imaging (DTI) was performed to try to depict the major parts of the visual pathway. The goal was to use an FDA approved standard commercial workstation which could be used for everyday routine in order to try to reduce postoperative damage of the visual pathway in the...
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相关实验视频

Updated: Jan 20, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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白物质的微观结构预测了努力和奖励灵敏度.

Nam Trinh1, Laurence Dricot2, Pierre Vassiliadis3

  • 1Centre for Research Training in Machine Learning (ML-Labs), School of Computing, Dublin City University, D09V209, Dublin, Ireland; Insight Research Ireland Centre for Data Analytics, School of Computing, Dublin City University, D09V209, Dublin, Ireland; Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon (CRNL), U1028 UMR5292, Impact Team, F-69500, Bron, France..

NeuroImage
|January 18, 2026
PubMed
概括

努力和奖励灵敏度的个体差异与大脑中的特定白质道有关. 补充运动区域 (SMA) 路径是这些目标导向行为变化的关键预测因素.

关键词:
扩散计量成像技术的使用.劳动力 劳动力处理 劳动力处理基于努力的决策.分数异构的分数异构.平均扩散性是指动机 激励 动机奖励处理奖励的处理.

更多相关视频

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相关实验视频

Last Updated: Jan 20, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学
  • 神经成像是一种神经成像.

背景情况:

  • 努力和奖励灵敏度的个体差异显著影响目标导向行为.
  • 这种变化的神经解剖学基础在很大程度上仍未被探索.
  • 了解这些差异对于解决诸如冷漠和冲动等疾病至关重要.

研究的目的:

  • 识别与努力和奖励灵敏度的个体差异相关的白质基质.
  • 研究大脑微观结构与决策之间的关系.
  • 探索白质特征对行为变化的预测能力.

主要方法:

  • 在45名健康参与者中,对努力和奖励灵敏度的综合计算建模与全脑扩散MRI.
  • 利用数据驱动的,基于集群的分数异构性和平均扩散性的分析.
  • 采用样本外,多类机器学习进行预测分析.

主要成果:

  • 确定了12个与努力 (前部估值节点) 和奖励灵敏度 (跨越多个网络) 相关的白质集群.
  • 在补充动力区域 (SMA) 连接的集群中发现了强烈的关联,一些在两个敏感度之间共享.
  • 证明特定的微观结构特征可靠地预测了个人对努力和奖励敏感性的差异,SMA途径是主要的预测因素.

结论:

  • 分布白质微观结构与个人之间的努力和奖励灵敏度差异相关.
  • 与SMA连接的路径作为调节这些行为特征的中心枢纽.
  • 局部化白质微观结构能够稳定地预测个体差异,为理解和潜在地干预目标导向行为提供框架.