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Updated: Jan 20, 2026

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
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Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

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谷氨酸受体和健康和疾病中的突触可塑性:个人的旅程

Graham L Collingridge1,2

  • 1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Hippocampus
|January 18, 2026
PubMed
概括

这项研究详细介绍了海马体内突触可塑性机制,揭示了谷氨酸受体如何影响记忆,并有助于阿尔茨海默病的进展和痴呆症触发.

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The protocol demonstrates that by performing microtransplantation of synaptic membranes into Xenopus laevis oocytes, it is possible to record consistent and reliable responses of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and γ-aminobutyric acid receptors.
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