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3'-adenosine 5'-phosphosulfate合成酶2 (PAPSS2) 是结肠腺癌的一个潜在的诊断和预后生物标志物

Andong Jin¹, Fengjing Yang², Hang Li¹

¹Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Scientific reports

|January 18, 2026

概括

在结肠癌中,酶3'-adenosine 5'-phosphosulfate (PAPS) 合成酶2 (PAPSS2) 的下调,与预后不佳和瘤细胞入侵增加相关. PAPSS2可以作为结肠腺癌的诊断和预后生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

结肠腺癌 (COAD) 对全球的健康构成重大负担.
3'-adenosine 5'-phosphosulfate (PAPS) 合成酶2 (PAPSS2) 对于硫化至关重要,但其在COAD中的作用尚未得到充分研究.

研究的目的:

研究PAPSS2在结肠腺癌中的表达,诊断,预后和免疫调节作用.
阐明PAPSS2对COAD细胞行为及其调节网络的功能影响.

主要方法:

在泛癌数据集 (TCGA,GEO) 和COAD组织中分析PAPSS2表达.
不同基因表达分析,对免疫细胞透的ssGSEA和单细胞水平分析.
在体外测试 (CCK8,EDU,伤口愈合,Transwell) 以评估扩散,迁移和入侵.

主要成果:

在COAD组织中,PAPSS2的表达显着较低,这与不良的临床参数和更差的预后有关.
PAPSS2表达与免疫细胞透,免疫调节因子和化学因子正相关.
抑制PAPSS2增强了COAD细胞的增殖,迁移和入侵,这意味着它在p53通路中的作用.

结论:

在COAD中,PAPSS2作为潜在的诊断和预后生物标志物起作用.
低调PAPSS2促进恶性进展,部分通过p53信号通路.
在结肠腺癌中,PAPSS2影响瘤免疫力和细胞功能.

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