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Updated: Jan 20, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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在急性髓性白血病中,BCOR突变定义了对DHODH抑制的治疗脆弱性

Florian Robert1,2, Cherif Badja3,4, Soraya Boushaki3,4

  • 1Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK. fr392@cam.ac.uk.

Annals of hematology
|January 18, 2026
PubMed
概括

使用现有药物向二基甲酸脱酶 (DHODH) 对具有BCOR突变的急性髓性白血病 (AML) 是有前途的. 抑制DHODH可以选择性地杀死BCOR突变癌细胞,提供一种新的精准医学方法.

关键词:
急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.这就是BCOR BCOR.DHODH DHODH 在线阅读DHODH 的抑制作用.在白血病中,白血病.合成杀伤性 合成杀伤性有针对性的治疗.

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