创伤性性颗粒瘤与流动性埃索诺菲利亚:临床病理学和分子分析
Jira Chansaenroj1, Ekarat Phattarataratip2, Thanaphum Osathanon1,3
1Faculty of Dentistry, Center of Excellence for Dental Stem Cell Biology, Chulalongkorn University, Bangkok, Thailand.
这项研究发现,创伤性性大质瘤与侧向性乙 (TUGSE) 主要影响老年人,病毒病原体似乎不会引起这些病变. 需要进一步的研究来了解TUGSE的发展.
科学领域:
- 口腔病理学 口腔病理学
- 皮肤病学 皮肤病学
- 传染病 传染病 传染病
背景情况:
- 创伤性性大质瘤与侧腔异敏性 (TUGSE) 是一种罕见的口腔病变.
- TUGSE的病因尚不清楚,病毒参与是可疑的因素.
研究的目的:
- 为了确定TUGSE的流行率和临床特征.
- 调查特定病毒病原体在TUGSE发展中的潜在作用.
主要方法:
- 追溯分析57例TUGSE病例和50例非特异性对照病例.
- 人口和临床数据的收集.
- 在组织样本中进行PCR查,检测埃普斯坦-巴尔病毒 (EBV),细胞巨乳病毒 (hCMV),人类乳头瘤病毒 (HPV),简单疹病毒 (HSV) 和Helicobacter pylori (H. pylori).
主要成果:
- 图格斯主要影响到60岁和70岁的人,女性倾向 (1:1.6的男性对女性比率).
- 舌头和口腔粘膜是TUGSE最常见的部位.
- 与非特异性相比,TUGSE病变表现出巨细胞透和炎症参与的增加;EBV在少数TUGSE病例中被检测到,而其他测试的病毒病原体无法检测到.
结论:
- TUGSE在老年人群中更为普遍,并显示出女性倾向.
- 病毒病原体的低检测率表明,它们可能不是TUGSE的主要原因.
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