相关实验视频
Updated: Jan 20, 2026
Inflammatory Bowel Disease II: Crohn's Disease
在患有炎症性肠病的儿科队列中,关于STRIDE-II治疗目标的真实数据
Marie-Luise Frank1, Thu Giang Le Thi1,2, Ina Schacker1
1Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Munich, Germany.
大多数儿科炎症性肠病 (IBD) 患者迅速实现了临床缓解和C反应蛋白 (CRP) 正常化. 然而,便calprotectin (FC) 的正常化需要更长的时间,并且复发很常见,特别是在性结肠炎 (UC) 中,这突显了持续监测的需要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠病 (IBD) 研究研究
- 处理到目标的策略.
背景情况:
- 在STRIDE (在炎症性肠病中选择治疗点) 倡议中,建立了基于证据的点,用于IBD的治疗点策略.
- STRIDE-II将临床缓解,C反应蛋白 (CRP) 正常化和便calprotectin (FC) 降低作为短期到中期目标,而粘膜愈合作为长期目标.
研究的目的:
- 评估STRIDE-II目标在儿科炎性肠病 (IBD) 队列中的实际应用.
- 评估新诊断的儿科IBD患者在52周内实现疾病控制和治疗目标的时间.
主要方法:
- 在2017年6月至2023年1月期间接受治疗的74名新诊断的儿科IBD患者 (3-18岁) 的回顾性分析.
- 通过使用疾病活性指数,CRP,FC和内镜,评估52周的STRIDE-II目标实现时间和52周的第一次爆发时间.
主要成果:
- 临床缓解和CRP正常化发生在5-10周内;FC正常化在12-19周内.
- 在6个月后,54%的克罗恩病 (CD) 和43%的性结肠炎 (UC) 患者实现了联合目标.
- 复发率高于UC (67%) 比CD (43%);内镜治疗观察到CD的39%和UC患者的59%.
结论:
- 儿科IBD患者经常在STRIDE-II时间框架内实现临床缓解和CRP正常化.
- 便calprotectin的正常化延迟,复发,特别是UC,仍然是一个问题.
- 在大量儿科IBD患者中,低于最佳的疾病控制需要持续监测和可能调整的治疗策略.
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