在2型糖尿病中,术前的SGLT2抑制剂和气管切除术后的术后并发症
Sohil Singh1, Sagar Singh Matharu1, Ankit Choudhury1
1Medical School, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
The Laryngoscope
|January 19, 2026
概括
在接受开放性外科气管切除的2型糖尿病成年人中,手术前使用-葡萄糖携带载体2抑制剂 (SGLT2i) 与手术后心力衰竭恶化和低血糖症的风险更高有关.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 外科手术的结果
背景情况:
- 2型糖尿病 (T2DM) 管理涉及各种药物,包括SGLT2抑制剂.
- 开放式外科气管切除术 (OST) 是一种带有特定术后风险的手术.
- 在接受OST的患者中,SGLT2抑制剂的外科影响尚不清楚.
研究的目的:
- 调查手术前使用SGLT2抑制剂与在接受OST的T2DM患者手术后并发症之间的关联.
- 评估特定的并发症,如心力衰竭恶化和低血糖症.
主要方法:
- 使用多机构电子健康记录网络进行的回顾性队列研究.
- 在2013-2024年期间接受OST的确定的T2DM患者.
- 倾向性得分与基于人口统计,并发症和手术前因素的平衡队列相匹配.
主要成果:
- 使用SGLT2抑制剂与心力衰竭恶化几率在OST后90天和180天增加有关.
- 在SGLT2抑制剂组中,在180天后观察到低血糖的几率增加.
- 没有发现外科手术部位感染或气管口腔静脉口腔功能障碍的显著关联.
结论:
- 在接受OST的T2DM患者中,手术前使用SGLT2抑制剂与术后低血糖和心力衰竭恶化程度较高有关.
- 结果表明,在高风险的呼吸道手术中,SGLT2抑制剂的术前管理需要谨慎.
- 需要进一步的前性研究来确定最佳的SGLT2抑制剂中止策略.
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