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增加mROS生成与BioHEART-CT PBMC中的心血管风险相关

W Eugene Lee^1,2, Albert Henry³, Eleanor Ruth Spenceley^3,4

¹Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Clinical and translational science

|January 19, 2026

概括

血液细胞中的线粒体反应性氧物种 (mROS) 不是冠状动脉疾病 (CAD) 的可靠生物标志物. 需要进一步的研究,以确定有效的基于血液的标志物用于心血管疾病.

科学领域:

心血管研究研究心血管研究
生物标志物发现发现
免疫学免疫学免疫学

背景情况:

冠状动脉疾病 (CAD) 是一个主要的全球健康问题,需要识别可访问的血液生物标志物.
氧化应激和免疫细胞功能障碍与动脉样硬化有关,这是CAD的潜在病理.

研究的目的:

为了研究线粒体反应性氧物种 (mROS) 在外周血液单核细胞 (PBMCs) 和 CAD.生产之间的关联.
探索与CAD相关的PBMC种群中CCBE1基因的差异表达.

主要方法:

从40名CT定义CAD或没有CT定义CAD的参与者中分析PBMC,使用基于MitoSOX的流细胞计测量以测量mROS.
单细胞RNA测序 (scRNA-seq) 用于评估跨PBMC亚型的CCBE1基因表达.

主要成果:

PBMC mROS水平与CAD状态或心血管风险因素没有一致的关联.
探索性亚组分析揭示了对淋巴细胞和单细胞mROS的有限,不统一的信号.
scRNA-seq没有在PBMC中识别出明显的CCBE1表达特征.

结论:

从PBMC衍生的mROS不太可能成为稳定种群中CAD的有用的横截面生物标志物.
目前的发现不支持在PBMC中使用mROS作为冠状动脉疾病的一般生物标志物.

关键词:

这就是PBMCs.动脉样硬化动脉样硬化生物标志物生物标志物冠状动脉疾病是一种冠状动脉疾病.功能障碍功能障碍是指一种功能障碍.线粒体中的线粒体.

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